Characterization of doxorubicin-nonproducing mutant, Nu3 of Streptomyces peucetius ATCC27952

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Title
Characterization of doxorubicin-nonproducing mutant, Nu3 of Streptomyces peucetius ATCC27952
Author(s)
Cheol Kyu Hwang; Hong-Sub Lee; Young Soo Hong; Nam-Soo Paek; Tae-Han Kim; Jung Joon Lee
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 7, no. 5, pp. 363-366
Publication Year
1997
Abstract
A doxorubicin-nonproducing mutant, Nu23 was selected from the mutagenesis of Streptomyces peucetius ATCC27952. Chemical and molecular biological analysis suggested that the mutant was blocked at the step between polyketide synthase and aklaviketon reductase in the biosynthesis of doxorubicin. Furthermore, the bioconversion experiment with the mutant revealed that 13-dihydrodaunorubicin is likely to be a biosynthetic intermediate.
Keyword
BioconversionMutantStreptomyces peucetius
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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