Characterization of doxorubicin-nonproducing mutant, Nu3 of Streptomyces peucetius ATCC27952
Cited 0 time in 
Metadata Downloads
- Title
- Characterization of doxorubicin-nonproducing mutant, Nu3 of Streptomyces peucetius ATCC27952
- Author(s)
- Cheol Kyu Hwang; Hong-Sub Lee; Young Soo Hong; Nam-Soo Paek; Tae-Han Kim; Jung Joon Lee
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 7, no. 5, pp. 363-366
- Publication Year
- 1997
- Abstract
- A doxorubicin-nonproducing mutant, Nu23 was selected from the mutagenesis of Streptomyces peucetius ATCC27952. Chemical and molecular biological analysis suggested that the mutant was blocked at the step between polyketide synthase and aklaviketon reductase in the biosynthesis of doxorubicin. Furthermore, the bioconversion experiment with the mutant revealed that 13-dihydrodaunorubicin is likely to be a biosynthetic intermediate.
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.