Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

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Title
Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design
Author(s)
Kwang Hee Son; Yong Guk Kwon; Kyung Sook Bae; Young Kook Kim; Byoung-Mog Kwon; Sung Uk Kim; Song Hae Bok
Bibliographic Citation
Biotechnology Letters, vol. 20, no. 2, pp. 149-151
Publication Year
1998
Abstract
Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1005324407319
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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