Inhibition of phospholipase C activity by auriculatin and 8-prenylluteone isolated from Erythrina senegalensis

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Title
Inhibition of phospholipase C activity by auriculatin and 8-prenylluteone isolated from Erythrina senegalensis
Author(s)
Won Keun Oh; Hyun Sun Lee; Bo Yeon Kim; Hye Kyung Chang; Yong Hae Kim; Jean Wandji; J Tanyl Mbafor; Tanee Fomum; Jong Seog Ahn
Bibliographic Citation
Phytotherapy Research, vol. 12, no. 1, pp. 9-12
Publication Year
1998
Abstract
Auriculatin and 8-prenylluteone were isolated from Erythrina senegalensis (Leguminosae) as inhibitors of phospholipase C (PLC) and phosphoinositides (PI)-turnover in PLC-γ1 overexpressing NIH3T3 fibroblasts (NIH3T3γ1). Auriculatin (1) and 8-prenylluteone (2) showed inhibitory activity with an IC50 value of 20 μM on PLC in vitro as well as the formation of inositol phosphates in platelet-derived growth factor (PDGF)-stimulated NIH3T3γ1 cells. They also showed a moderate cytotoxicity against several human tumour cell lines with an IC50 of 9.0-20 μm, i.e. PC-3 (prostate), NCI-H226 (lung), CRL1579 (melanoma) in vitro.
Keyword
phospholipase Ctotal inositol phosphatesauriculatin8-prenylluteoneErythrina senegalensisLeguminosae
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/(sici)1099-1573(19980201)12:1<9::aid-ptr175>3.0.co;2-%23
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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