Synthesis and In vitro cytotoxicity of cinnamaldehydes to human solid tumor cells

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Synthesis and In vitro cytotoxicity of cinnamaldehydes to human solid tumor cells
Byoung-Mog Kwon; Seung Ho Lee; Sang Un Choi; Sung Hee Park; Chong Ock Lee; Young Kwon Cho; Nack Do Sung; Song Hae Bok
Bibliographic Citation
Archives of Pharmacal Research, vol. 21, no. 2, pp. 147-152
Publication Year
Cinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the 2′-hydroxycinnamaldehyde isolated from the bark of Cinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 μg/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaldehyde analogues which showed ED50 values 0.63∼8.1 μg/ml. Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group.
CinnamaldehydeHuman tumor cellCytotoxicityCinnamomum cassia
Pharmaceutical Soc Korea
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