Multidrug-resistance reversing activity of medicinal plants = 약용 식물의 암세포 다제내성 조절 활성 검색

Cited 0 time in scopus
Metadata Downloads
Title
Multidrug-resistance reversing activity of medicinal plants = 약용 식물의 암세포 다제내성 조절 활성 검색
Author(s)
Se Eun Kim; Bang yeon hwang; Young Ho Kim; Young Jung Kim; Kyung Soon Lee; Jung Joon Lee
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 28, no. 4, pp. 174-178
Publication Year
1997
Abstract
Methanol extracts from 450 plants were screened for multidrug-resistance reversing activity using drug sensitive KB-3-1 and multidrug-resistance KB- V1 cells. Among them, the extracts of Cynanchum wilfordii. Torilis japonica. Celastrus orbiculatus. Melia toosendan and Terminalia chebula strongly potentiated vinblastine cytotoxicity in KB-V1 cells. But their cytotoxicities to both sensitive KB-3-1 and resistant KB-V1 cells were in the same order of magnitude. These results indicate that the above samples would contain the active principles which do not exert their activity solely by cytotoxicity.
Keyword
multidrug-resistance (MDR)vinblastineCynanchum wilfordiiTorilis japonicaCelastrus orbiculatusMelia toosendanTerminalia chebula
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.