Mode of action of torilin in multidrug-resistant cancer cell lines

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Title
Mode of action of torilin in multidrug-resistant cancer cell lines
Author(s)
Se Eun Kim; Young Soo Hong; Young Choog Kim; Jung Joon Lee
Bibliographic Citation
Planta Medica, vol. 64, pp. 335-338
Publication Year
1998
Abstract
The mechanism of action of multidrug-resistance reversing activity of torilin was studied. In vitro experiments for the accumulation and efflux of vinblastine clearly indicated that MDR reversing effect of torilin would directly be associated with the increase of the intracellular accumulation of anticancer drugs by blocking the drug efflux. Furthermore, torilin increased the membrane ATPase activity from KB-V1 cells, suggesting that torilin might function by inhibiting drug transport mediated by P-glycoprotein.
Keyword
TorilinTorilis japonicaUmbelliferaemultidrug-resistance (MDR)drug accumulation and effluxmembrane ATPasedrug transport
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-957446
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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