Mode of action of torilin in multidrug-resistant cancer cell lines
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- Title
- Mode of action of torilin in multidrug-resistant cancer cell lines
- Author(s)
- Se Eun Kim; Young Soo Hong; Young Choog Kim; Jung Joon Lee
- Bibliographic Citation
- Planta Medica, vol. 64, pp. 335-338
- Publication Year
- 1998
- Abstract
- The mechanism of action of multidrug-resistance reversing activity of torilin was studied. In vitro experiments for the accumulation and efflux of vinblastine clearly indicated that MDR reversing effect of torilin would directly be associated with the increase of the intracellular accumulation of anticancer drugs by blocking the drug efflux. Furthermore, torilin increased the membrane ATPase activity from KB-V1 cells, suggesting that torilin might function by inhibiting drug transport mediated by P-glycoprotein.
- Keyword
- drug accumulation and effluxmembrane ATPasedrug transportmultidrug-resistance (MDR)TorilinTorilis japonicaUmbelliferae
- ISSN
- 0032-0943
- Publisher
- Georg Thieme Verlag Kg
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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