A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells

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Title
A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells
Author(s)
Se Eun Kim; Young Ho Kim; Jung Joon Lee
Bibliographic Citation
Journal of Natural Products, vol. 61, pp. 108-111
Publication Year
1998
Abstract
In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1β,2β- diacetoxy-6α,9α-bis(benzoyloxy)dihydro-β-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np9702392
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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