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- Title
- A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells
- Author(s)
- Se Eun Kim; Young Ho Kim; Jung Joon Lee
- Bibliographic Citation
- Journal of Natural Products, vol. 61, pp. 108-111
- Publication Year
- 1998
- Abstract
- In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1β,2β- diacetoxy-6α,9α-bis(benzoyloxy)dihydro-β-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.
- ISSN
- 0163-3864
- Publisher
- Amer Chem Soc
- DOI
- http://dx.doi.org/10.1021/np9702392
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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