Phospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba

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Title
Phospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba
Author(s)
Ji Suk Lee; You Sun Cho; Eun Jung Park; Jin Woong Kim; Won Keun Oh; Hyun Sun Lee; Jong Seog Ahn
Bibliographic Citation
Journal of Natural Products, vol. 61, no. 7, pp. 867-871
Publication Year
1998
Abstract
Ten phenolic compounds were isolated from the CHCl3 extract of Ginkgo biloba sarcotestas (Ginkgoaceae) as a new class of phosphatidylinositol- specific phospholipase Cγ1 (PI-PLCγ1) inhibitors. The substances without the long chain were ineffective: On the other hand, the activities of these compounds were dramatically decreased by acetylation of aromatic hydroxyl groups of cardanol, phenolic acid, and bilobol and by methylation of the aromatic carboxyl group of phenolic acid. The unsaturated long chain as well as the aromatic hydroxyl and carboxyl groups might play a key role for the PI-PLCγ1 inhibitory activity. These compounds also inhibited the growth of a number of human cancer cell lines, but were less cytotoxic against a human normal colon cell line.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np970367q
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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