Inhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase

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Title
Inhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase
Author(s)
Jae Yoon Leem; Ho Yong Park; Hidesuke Fukazawa; Yoshimasa Uehara; Shunji Natori
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 21, no. 7, pp. 784-785
Publication Year
1998
Abstract
We examined the inhibitory effects of N-β-alanyl-5-S-glutathionyl-3,4- dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. We found that 5-S-GAD directly inhibited not only tyrosine phosphorylation of PTK p60(v-src), but also tyrosine phosphorylation of PTK p210(BCR-ABL). The inhibitory potency of 5-S-GAD was comparable to that of radicicol and herbimycin A of PTK inhibitor.
Keyword
5-S-GADantibacterial substanceinsect immunityinhibition of PTKsP60(v-src)P210(BCR-ABL)
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.21.784
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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