Chaetoglobosin A, an inhibitor of Bleb formation on K562 cells induced by phorbol 12,13-dibutyrate

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Title
Chaetoglobosin A, an inhibitor of Bleb formation on K562 cells induced by phorbol 12,13-dibutyrate
Author(s)
Hack Ryong Ko; Bo Yeon Kim; Soon Cheol Ahn; Won Keun Oh; Jin Hee Kim; Hyun Sun Lee; Hwan Mook Kim; Sang Bae Han; Tae Ick Mheen; Jong Seog Ahn
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 8, no. 6, pp. 705-709
Publication Year
1998
Abstract
In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12,13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the IC50 value of 60 pM against bleb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.
Keyword
Bleb formationinhibitorPDBuK562 cellschaetoglobosin A
ISSN
1017-7825
Publisher
South Korea
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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