Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

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Title
Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent
Author(s)
Kyung Seop Ahn; Moon Sun Hahm; Eun Jin Park; Hyeong Kyu Lee; Ik Hwan Kim
Bibliographic Citation
Planta Medica, vol. 64, pp. 468-470
Publication Year
1998
Abstract
Corosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-957487
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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