Cloning and sequence analysis of cDNAs encoding the heavy and light chain variable regions of a human monoclonal antibody with specificity for hepatitis B surface antigen

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Title
Cloning and sequence analysis of cDNAs encoding the heavy and light chain variable regions of a human monoclonal antibody with specificity for hepatitis B surface antigen
Author(s)
Chun Jeih Ryu; Hong Keun Chung; Hyo Jeong Hong
Bibliographic Citation
Biochimica et Biophysica Acta-General Subjects, vol. 1380, no. 2, pp. 151-155
Publication Year
1998
Abstract
We cloned and analyzed the cDNA sequences encoding the variable regions of a human monoclonal antibody (23HN) (γ I, κ) that binds to the common a antigenic determinant on hepatitis B surface antigen and its fine epitope is different from those of previously known mAbs with the same specificity. The heavy and light chain variable regions are the members of human heavy chain subgroup III and kappa light chain subgroup III, respectively, and are most homologous to human germline V(H) segment DP-50 and V3κ segment DPK-22, respectively.
Keyword
Anti-HBsAg antibodyNucleotide sequenceAntibody diversity(Human)Monoclonal antibody
ISSN
0304-4165
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0304-4165(98)00006-3
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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