Open Access@KRIBBDivision of A.I. & Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
Chitin synthase II inhibitory activity of urosolic acid, isolated from Crataegus pinnatifida
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- Title
- Chitin synthase II inhibitory activity of urosolic acid, isolated from Crataegus pinnatifida
- Author(s)
- Tae Sook Jeong; Eui Il Hwang; Hyang Bok Lee; Eun Sook Lee; Young Kook Kim; Byung Sun Min; Ki Hwan Bae; Song Hae Bok; Sung Uk Kim
- Bibliographic Citation
- Planta Medica, vol. 65, no. 3, pp. 261-263
- Publication Year
- 1999
- Abstract
- Two triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 μ/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 μg/ml. Oleanolic acid, α-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7 μg/ml, respectively.
- ISSN
- 0032-0943
- Publisher
- Georg Thieme Verlag Kg
- Full Text Link
- http://dx.doi.org/10.1055/s-2006-960474
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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