Chitin synthase II inhibitory activity of urosolic acid, isolated from Crataegus pinnatifida

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Title
Chitin synthase II inhibitory activity of urosolic acid, isolated from Crataegus pinnatifida
Author(s)
Tae Sook Jeong; Eui Il Hwang; Hyang Bok Lee; Eun Sook Lee; Young Kook Kim; Byung Sun Min; Ki Hwan Bae; Song Hae Bok; Sung Uk Kim
Bibliographic Citation
Planta Medica, vol. 65, no. 3, pp. 261-263
Publication Year
1999
Abstract
Two triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 μ/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 μg/ml. Oleanolic acid, α-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7 μg/ml, respectively.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-960474
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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