FTPase 저해활성 : 1-아자안트라퀴논 유도체

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Title
FTPase 저해활성 : 1-아자안트라퀴논 유도체
Author(s)
Hee Soon Lee; Seung Ho Lee; Seoung Soo Hong; Ji Youn Nam; Byoung-Mog Kwon
Bibliographic Citation
Chungbuk Jurnal of Pharmaceutical Sciences, vol. 13, pp. 71-78
Publication Year
1998
Abstract
Inhibitory activity of twenty four 3- or 4- substituted - I - azaanthraquinones were studied on Farnesyl protein transferase (FPTase) and Srchomology 2 domain (SH2) binding. The most activi compound 16 showed 76.7% inhibition on FPTase at 100μg/ml and 64.4% inhibition of SH2 at 50μg/ml.
ISSN
I000-0115
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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