Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists
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- Title
- Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists
- Author(s)
- Im Seon Lee; Keun Young Jung; Sei Ryang Oh; Si Hyung Park; Kyung Seop Ahn; Hyeong Kyu Lee
- Bibliographic Citation
- Biological & Pharmaceutical Bulletin, vol. 22, no. 3, pp. 265-267
- Publication Year
- 1999
- Abstract
- We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1 x 10-6 M) in this study.
- ISSN
- 0918-6158
- Publisher
- Pharmaceutical Soc Japan
- Full Text Link
- http://dx.doi.org/10.1248/bpb.22.265
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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