In vitro anticomplementary activity of hederagenin saponins isolated from roots of dipsacus asper

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Title
In vitro anticomplementary activity of hederagenin saponins isolated from roots of dipsacus asper
Author(s)
Sei Ryang Oh; Keun Young Jung; Kun Ho Son; Si Hyung Park; Im Seon Lee; Kyung Seop Ahn; Hyeong Kyu Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 22, no. 3, pp. 317-319
Publication Year
1999
Abstract
Anticomplementary activity of hederagenin and related saponins isolated from Dipsacus asper was investigated in vitro. HN saponin F (3) was most potent with IC50 value of 3.7×10-5 M followed by 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)- β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (8), 3-O-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (5), dipsacus saponin A (4), and hederagenin (1) on the classical pathway (CP) of complement system, while the saponins 3-5 did not show the inhibition of hemolysis and rather increase the hemolysis on the alternative pathway (AP). However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes.
Keyword
Anticomplementary activityHederageninHederagenin saponinsDipsacus asper
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976371
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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