Antitumor effects of IL-6 on murine liver tumor cells in vivo

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Title
Antitumor effects of IL-6 on murine liver tumor cells in vivo
Author(s)
Hyung Sik Kang; Dae Ho Cho; Sung Sook Kim; Kwang Ho Pyun; In Pyo Choi
Bibliographic Citation
Journal of Biomedical Science, vol. 6, no. 2, pp. 142-144
Publication Year
1999
Abstract
IL-6 is a pleiotropic cytokine that is capable of modulating the diverse functions of hepatocytes such as acute phase responses and inflammation in the liver. To learn its antitumor effects in vivo, the cDNA of IL-6 was transfected into murine liver cells, TIB cells. IL-6-transfected TIB cells (TIB73-IL-6 or TIB75-IL-6) produced much higher levels of IL-6 compared with vector-transfected TIB cells (TIB73-vec or TIB75-vec). To investigate the effects of IL-6 on TIB tumor growth in vivo, IL-6-transfected TIB cells or vector-transfected TIB cells were injected subcutaneously into syngeneic mice. Vector-transfected TIB cells grew rapidly 3 weeks after injection, but IL-6-transfected TIB cells did not grow at all for up to 6 weeks. Pathologically, IL-6-transfected TIB cells demonstrated a severe necrosis and apoptotic pattern. Taken together, these results indicate that IL-6 functions as a growth inhibiting factor in vivo, and another biological role of IL-6 in the liver is suggested.
Keyword
Liver tumorInterleukin-6Antitumor effectsHost immunity
ISSN
1021-7770
Publisher
Springer-BMC
DOI
http://dx.doi.org/10.1007/BF02256445
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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