Inhibition of nitric oxide production by coumarins from Peucedanum Japonicum in LPS-Activated RAW 264.7 cells = 갯기름나물의 쿠마린에 의한 RAW 264.7 세포주의 Nitric oxide 생성 저해활성

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Title
Inhibition of nitric oxide production by coumarins from Peucedanum Japonicum in LPS-Activated RAW 264.7 cells = 갯기름나물의 쿠마린에 의한 RAW 264.7 세포주의 Nitric oxide 생성 저해활성
Author(s)
Hee Cheol Choi; Tae Cheol Rho; Bo Yeon Kim; Hack Ryong Ko; Won Keun Oh; Chang Keun Seong; Tae Ick MheenJong Seog Ahn; Hyun Sun Lee
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 30, no. 2, pp. 99-104
Publication Year
1999
Abstract
During the screening for inhibitors of nitric oxide production in LPS- activated macrophage, RAW 264.7 cells. Five coumarins were isolated from chloroform extract of the root of Peucedanum japonicum. They were identified as praeruptorin A (1), xanthotoxin (2), psoralen (3), isopimpinellin (4), bergapten (5) on the basis of spectroscopic methods. The IC50 values for nitrite production by activated macrophages were about 1.5 μg/ml (1), 0.3 μg/ml (2), 1.0 μg/ml (3), 25 μg/ml (4), 25 μg/ml (5), respectively. However, the inducible nitric oxide synthase (iNOS) was not inhibited by treatment with these compounds. Their inhibitory effect on nitric oxide production was resulted from the suppression of iNOS expression.
Keyword
Peucedanum japonicumcoumarinsnitric oxideRAW 264.7 cellslipopolysaccharide (LPS), iNOS
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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