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- Title
- Anti-helicobacter pylori activity of quinolone alkaloids from evodiae fructus
- Author(s)
- Tae Cheol Rho; Eun Ah Bae; Dong Hyun Kim; Won Keun Oh; Bo Yeon Kim; Jong Seog Ahn; Hyun Sun Lee
- Bibliographic Citation
- Biological & Pharmaceutical Bulletin, vol. 22, no. 10, pp. 1141-1143
- Publication Year
- 1999
- Abstract
- A biologically monitored fractionation of methanol extract of the fruit of Evodia rutaecarpa led to the isolation of six quinolone alkaloids, evocarpine (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3), 1-methyl-2- undecyl-4(1H)-quinolone (4), dihydroevocarpine (5), 1-methyl-2-pentadecyl- 4(1H)-quinolone (6). They showed potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 μg/ml. However, they had no effect on Helicobacter pylori urease activity at the concentration of 300 μg/ml.
- Keyword
- Helicobacter pyloriEvodia rutaecarpaQuinolone alkaloid
- ISSN
- 0918-6158
- Publisher
- Pharmaceutical Soc Japan
- DOI
- http://dx.doi.org/10.1248/bpb.22.1141
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
- Files in This Item:
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