Anti-helicobacter pylori activity of quinolone alkaloids from evodiae fructus

Cited 40 time in scopus
Metadata Downloads
Title
Anti-helicobacter pylori activity of quinolone alkaloids from evodiae fructus
Author(s)
Tae Cheol Rho; Eun Ah Bae; Dong Hyun Kim; Won Keun Oh; Bo Yeon KimJong Seog Ahn; Hyun Sun Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 22, no. 10, pp. 1141-1143
Publication Year
1999
Abstract
A biologically monitored fractionation of methanol extract of the fruit of Evodia rutaecarpa led to the isolation of six quinolone alkaloids, evocarpine (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3), 1-methyl-2- undecyl-4(1H)-quinolone (4), dihydroevocarpine (5), 1-methyl-2-pentadecyl- 4(1H)-quinolone (6). They showed potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 μg/ml. However, they had no effect on Helicobacter pylori urease activity at the concentration of 300 μg/ml.
Keyword
Helicobacter pyloriEvodia rutaecarpaQuinolone alkaloid
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.22.1141
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.