Tylopeptins A and B, new antibiotic peptides from Tylopilus neofelleus

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Title
Tylopeptins A and B, new antibiotic peptides from Tylopilus neofelleus
Author(s)
Sang Jun Lee; Bong Sik Yun; Duck Hyun Cho; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 52, no. 11, pp. 998-1006
Publication Year
1999
Abstract
Two new peptides, tylopeptins A and B, were isolated from the methanol extract of the fruiting body of the mushroom, Tylopilus neofelleus. These peptides were identified as peptaibols possessing an acetylated N-terminal residue, fourteen amino acids, and leucinol as the C-terminal amino alcohol. Sequential determination and complete 1H and 13C resonance assignments were based on positive ion FAB mass spectroscopy and two dimensional NMR techniques. These peptides were subsequently shown to be active against some Gram-positive bacteria, but inactive against pathogenic fungi and Gram-negative bacteria.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.52.998
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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