Effects of retroviral-mediated Herpes Simplex Virus Thymidine Kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo

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Title
Effects of retroviral-mediated Herpes Simplex Virus Thymidine Kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo
Author(s)
Hyun Sang Cho; Young Nyun Park; Chuhl Joo Lyu; Chang Hyun Yang; Ki Yang Ryoo; Byung Soo Kim; Kir Young Kim; Yeon Soo Kim
Bibliographic Citation
Acta Oncologica, vol. 38, no. 8, pp. 1093-1097
Publication Year
1999
Abstract
Selective introduction of genes conferring chemosensitivity on proliferating tumor cells can be used to treat cancer. We investigated the efficacy of retrovirus-mediated gene transfer of the herpes simplex virus thymidine kinase (HSV-TK) gene to murine neuroblstoma cell lines [neuro-2a) in vitro and in vivo. Retrovirus-mediated HSV-TK gene transfer to the neuro- 2a cells resulted in sensitivity to ganciclovir (GCV) in vitro. In A/J mice, tumors produced from HSV-TK transduced neuro-2a cells regressed after GCV treatment. Intratumoral injection of recombinant retrovirus expressing HSV-TK gene also inhibited growth of the tumor established in A/J mice. These results demonstrate that HSV-TK gene therapy might be a feasible approach for inhibiting the growth of neuroblastoma.
ISSN
0284-186X
Publisher
T&F (Taylor & Francis)
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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