HIV integrase inhibitory activity of Agastache rugosa

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Title
HIV integrase inhibitory activity of Agastache rugosa
Author(s)
Hye Kyong Kim; Hyeong Kyu Lee; Cha Gyun Shin; Hoon Huh
Bibliographic Citation
Archives of Pharmacal Research, vol. 22, no. 5, pp. 520-523
Publication Year
1999
Abstract
We have been screening anti-HIV integrase compounds from Korean medicinal plants by using an in vitro assay system which is mainly composed of recombinant human immunodeficency virus type 1 integrase and radiolabeled oligonucleotides. From the above screening, the aqueous methanolic extract of the roots of Agastache rugosa exhibited a significant activity. Bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. The structure of the compound was determined by spectroscopic data and by the comparison with the reported values. The IC50 of the rosmarinic acid was approximately 10 μg/ml against HIV integrase.
Keyword
HIV integraseAgastache rugosaLabiataeRosmarinic acid
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02979163
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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