Brevibacterium ketoglutamicum을 이용한 L-ornithine 생산 연구 part 1 : L-ornithine 생산 고역가 안정화 균주 선발

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Title
Brevibacterium ketoglutamicum을 이용한 L-ornithine 생산 연구 part 1 : L-ornithine 생산 고역가 안정화 균주 선발
Author(s)
Wuk Sang Ryu; Hyung Wook Jang; Hong Weon Lee; Joon ki Jung; Soon Jae Chang; Yeon Woo Ryu; Young Hoon Park
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 27, no. 4, pp. 292-297
Publication Year
1999
Abstract
Over production of L-ornithine by mutant strains isolated from Brevibacterium ketoglutamicum BK1046 was investigated. The strain was a L- citrulline auxotroph and exhibited culture instability during fermentation. Through a sequential screening effort, a highly stable strain with less revertant formation was finally selected and designated B. ketoglutamicum BK52 (KCTC 0141BP). It produced L-ornithine at a high concentration (above 9 g/L) independent of subculture or cultivation time, and also had a very low tendency of revertant formation. In a long-term storage, this strain maintained its cell stability and productivity of L-ornithine to a reasonable range.
Keyword
L-ornithinerevertant formationcell stability
ISSN
0257-2389
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > 1. Journal Articles
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