Immunomodulating activity of a polysaccharide isolated from mori cortex radicis

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Title
Immunomodulating activity of a polysaccharide isolated from mori cortex radicis
Author(s)
Hwan Mook Kim; Sang Bae Han; Ki Hoon LeeChang Woo Lee; Chul Young Kim; Eun Ju Lee; Hoon Huh
Bibliographic Citation
Archives of Pharmacal Research, vol. 23, no. 3, pp. 240-242
Publication Year
2000
Abstract
The immunomodulating activity of a polysaccharide isolated from Morus alba (PMA) root bark was examined in murine splenic lymphocytes. PMA enhanced proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. However, PMA suppressed primary IgM antibody production from B cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a T-cell dependent antigen sheep red blood cells. Our observations showed that the immunomodulating activity of PMA increased lymphocyte proliferation and that PMA decreased antibody production from B cells, which was distinct from those of other plant-originated polysaccharides.
Keyword
immunomodulationMorus albapolysaccharideproliferationdifferentiationantibody production
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976452
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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