Flavonol glycoside gallate and ferulate esters from Persicaria lapathifolia as inhibitors of superoxide production in human monocytes stimulated by unopsonized zymosan

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Title
Flavonol glycoside gallate and ferulate esters from Persicaria lapathifolia as inhibitors of superoxide production in human monocytes stimulated by unopsonized zymosan
Author(s)
Young Soo Kim; Dae Sig Jang; Si Hyung Park; Ji Eun Yun; Bo Kyung Min; Kyung Rak Min; Hyeong Kyu Lee
Bibliographic Citation
Planta Medica, vol. 66, no. 1, pp. 72-74
Publication Year
2000
Abstract
Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-β- (2''-galloyl)-glucopyranoside and quercetin 3-O-β-(2''-galloyl)- rhamnopyranoside, and a new compound, quercetin 3-O-β-(6''-feruloyl)- galactopyranoside, were isolated as the inhibitors of superoxide production by activity-guided fractionation. IC50 values were shown at the concentrations of 2.1 μM by quercetin 3-O-β-(2''-galloyl)-glucopyranoside, 1.9 μM by quercetin 3-O-β-(2''-galloyl)-rhamnoypranoside, and 3.5 μM by quercetin 3-O-β-(6''-feruloyl)-galactopyranoside whose inhibitory potencies were similar to oxyphenylbutazone (IC50 = 1.9 μM) as a positive control.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-0029-1243112
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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