Effects of triterpenoids from Pueraria lobata on immunohemolysis: β-d-glucuronic acid plays an active role in anticomplementary activity in vitro
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- Effects of triterpenoids from Pueraria lobata on immunohemolysis: β-d-glucuronic acid plays an active role in anticomplementary activity in vitro
- Sei Ryang Oh; Junei Kinjo; Yuichi Shii; Tuyoshi Ikeda; Toshihiro Nohara; Kyung Seop Ahn; Jung Hee Kim; Hyeong Kyu Lee
- Bibliographic Citation
- Planta Medica, vol. 66, no. 6, pp. 506-510
- Publication Year
- The anticomplementary properties of kaikasaponin III (4) and soyasaponin I (8) from Pueraria Iobata and their hydrolytic analogs were investigated in vitro. Diglycosidic saponins [kaikasaponin I (3), soyasaponin III (7)] showed most potent anticomplementary activities, followed by monoglycosidic saponins [soyasapogenol B monoglucuronide (6), sophoradiol monoglucuronide (2)] and triglycosidic saponins [soyasaponin I (8), kaikasaponin III (4)], whereas sophoradiol (1) and soyasapogenol B (5) showed enhancement of hemolysis under the presence of serum on the classical pathway of complement system. But all of them showed very weak or no anticomplementary activities on the alternative pathway of complement system. The anticomplementary activity of the saponins was influenced by the nature of glucuronic acid, where the free acid forms (-COOH) showed much more potent activity than the sodium salt forms (-COO-Na+) or methyl ester forms (-COOCH3), and the reduced forms (-CH2OH) decreased the activity significantly.
- Anticomplementary activity, glucuronic acid of saponin; Leguminosae; Pueraria Iobata; Sophoradiol saponins; Soyasapogenol B saponins
- Georg Thieme Verlag Kg
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- Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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