Effects of triterpenoids from Pueraria lobata on immunohemolysis: β-d-glucuronic acid plays an active role in anticomplementary activity in vitro

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Title
Effects of triterpenoids from Pueraria lobata on immunohemolysis: β-d-glucuronic acid plays an active role in anticomplementary activity in vitro
Author(s)
Sei Ryang Oh; Junei Kinjo; Yuichi Shii; Tuyoshi Ikeda; Toshihiro Nohara; Kyung Seop AhnJung Hee Kim; Hyeong Kyu Lee
Bibliographic Citation
Planta Medica, vol. 66, no. 6, pp. 506-510
Publication Year
2000
Abstract
The anticomplementary properties of kaikasaponin III (4) and soyasaponin I (8) from Pueraria Iobata and their hydrolytic analogs were investigated in vitro. Diglycosidic saponins [kaikasaponin I (3), soyasaponin III (7)] showed most potent anticomplementary activities, followed by monoglycosidic saponins [soyasapogenol B monoglucuronide (6), sophoradiol monoglucuronide (2)] and triglycosidic saponins [soyasaponin I (8), kaikasaponin III (4)], whereas sophoradiol (1) and soyasapogenol B (5) showed enhancement of hemolysis under the presence of serum on the classical pathway of complement system. But all of them showed very weak or no anticomplementary activities on the alternative pathway of complement system. The anticomplementary activity of the saponins was influenced by the nature of glucuronic acid, where the free acid forms (-COOH) showed much more potent activity than the sodium salt forms (-COO-Na+) or methyl ester forms (-COOCH3), and the reduced forms (-CH2OH) decreased the activity significantly.
Keyword
Anticomplementary activity, glucuronic acid of saponinLeguminosaePueraria IobataSophoradiol saponinsSoyasapogenol B saponins
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2000-8614
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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