Open Access@KRIBBDivision of A.I. & Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor
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- Title
- 8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor
- Author(s)
- Ji Youn Nam; Hyae Kyeong Kim; Ju Young Kwon; Mi Young Han; Kwang Hee Son; U C Lee; J D Choi; Byoung-Mog Kwon
- Bibliographic Citation
- Journal of Natural Products, vol. 63, no. 9, pp. 1303-1305
- Publication Year
- 2000
- Abstract
- A new secondary metabolite, 8-O-methylsclerotiorinamine (1), was isolated from a strain of Penicillium multicolor, and its structure was established using NMR spectroscopy and chemical evidence. The metabolite inhibited significantly the binding between the Grb2-SH2 domain and the phosphopeptide derived from the Shc protein and also blocked the protein - protein interactions of Grb2-Shc in cell-based experiments, with IC50 values of 5.3 and 50 μM, respectively.
- ISSN
- 0163-3864
- Publisher
- Amer Chem Soc
- Full Text Link
- http://dx.doi.org/10.1021/np0001169
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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