8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor

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Title
8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor
Author(s)
Ji Youn Nam; Hyae Kyeong Kim; Ju Young Kwon; Mi Young Han; Kwang Hee Son; U C Lee; J D Choi; Byoung-Mog Kwon
Bibliographic Citation
Journal of Natural Products, vol. 63, no. 9, pp. 1303-1305
Publication Year
2000
Abstract
A new secondary metabolite, 8-O-methylsclerotiorinamine (1), was isolated from a strain of Penicillium multicolor, and its structure was established using NMR spectroscopy and chemical evidence. The metabolite inhibited significantly the binding between the Grb2-SH2 domain and the phosphopeptide derived from the Shc protein and also blocked the protein - protein interactions of Grb2-Shc in cell-based experiments, with IC50 values of 5.3 and 50 μM, respectively.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np0001169
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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