Interleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells

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Title
Interleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells
Author(s)
Young Han Lee; Sun Sik Bae; Jeong Kon Seo; Inpyo Choi; Sung Ho Ryu; Pann Gill Suh
Bibliographic Citation
Molecules and Cells, vol. 10, no. 4, pp. 469-474
Publication Year
2000
Abstract
Phospholipase C (PLC)-γ1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-γ1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-γ1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-γ1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation.
Keyword
interleukin 6PC12 cellsphospholipase C-γ1signal transductiontyrosine phosphorylation
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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