Cyclo(Dehydroala-l-Leu), an α-glucosidase inhibitor from Penicillium sp. F70614

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Title
Cyclo(Dehydroala-l-Leu), an α-glucosidase inhibitor from Penicillium sp. F70614
Author(s)
Oh Sung Kwon; Sang Ho Park; Bong Sik Yun; Yu Ryang Pyun; Chang Jin Kim
Bibliographic Citation
Journal of Antibiotics, vol. 53, no. 9, pp. 954-958
Publication Year
2000
Abstract
A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast α-glucosidase and porcine intestinal α-glucosidase with IC50 values of 35 and 50 μg/ml, respectively. However, it did not show significant inhibitory effects against almond β-glucosidase, Aspergillus α-galactosidase, Escherichia coli β-galactosidase and jack bean α-mannosidase.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.53.954
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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