Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla

Cited 0 time in scopus
Metadata Downloads
Title
Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla
Author(s)
Ji Suk Lee; Jin Woong Kim; Bo Yeon KimHyun Sun LeeJong Seog Ahn; Yuan Shiun Chang
Bibliographic Citation
Journal of Natural Products, vol. 63, no. 6, pp. 753-756
Publication Year
2000
Abstract
Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase Cγ1 (PLCγ1) inhibitors (1-6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCγ1 in vitro with IC50 values of 9.5-44.6 μM and inhibited the proliferation of human cancer cells with IC50 values of 0.5-6.5 μg/mL.
ISSN
0163-3864
Publisher
Amer Chem Soc
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.