Anti-apoptotic effects of terrein on etoposide-induced apoptosis of U937 human leukemia cells = Terrein의 etoposide에 의해 유도된 apoptosis 저해효과

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Title
Anti-apoptotic effects of terrein on etoposide-induced apoptosis of U937 human leukemia cells = Terrein의 etoposide에 의해 유도된 apoptosis 저해효과
Author(s)
Choong Hwan Lee; Ho Jae Lee; Jin Hee Kim; Hyun A Kim; Yung Hee Kho
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 28, no. 2, pp. 87-91
Publication Year
2000
Abstract
In the course of screening for the substances inhibiting apoptosis of U937 human leukemia cell induced by etoposide, a fungal strain F80834 producing a high level of inhibitor was selected. The inhibitory substance was purified and identified as terrein by spectroscopic methods of UV, EI-MS, 1H-NMR, 13C-NMR and DEPT. Terrein showed inhibitory activity of caspase 3, a major protease of apoptosis cascade, with an IC50 value of 20 μg/ml after 7 hrs of treatment. It also showed protective effect against cell death with an IC50 value of 10 μg/ml on U937 cells induced by etoposide after 24 hrs of treatment, but did not show any cytotoxicity at the same condition without etoposide.
Keyword
apoptosisinhibitorterreinetoposideU937 cells
ISSN
0257-2389
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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