Tumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases

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Title
Tumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases
Author(s)
S H Kim; W H Lee; B S Kwon; Goo Taeg Oh; Y H Choi; J E Park
Bibliographic Citation
Japanese Circulation Journal, vol. 65, no. 2, pp. 136-138
Publication Year
2001
Abstract
Immunohistochemical staining of human atherosclerotic plaques revealed expression of the tumor necrosis factor receptor superfamily (TNFRSF) 12 in regions rich in macrophage/foam cells. The role of TNFRSF12 in the functioning of monocytes in relation to atherogenesis was investigated by analysis of cellular events after stimulation of TNFRSF12 in a human macrophage-like cell line, THP-1. Activation of the THP-1 cells on plates coated with monoclonal antibody against TNFRSF12 induced the expression of matrix metalloproteinases (MMPs) -1, -9, and -13. Furthermore, the expression patterns of TNFRSF12 and the MMPs overlapped in atherosclerotic plaques. Signaling of TNFRSF12 may thus contribute to the induction of extracellular matrix degrading enzymes in macrophages.
Keyword
atherosclerosismatrix metalloproteinasetumor necrosis factor receptor superfamily
ISSN
0047-1828
DOI
http://dx.doi.org/10.1253/jcj.65.136
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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