Age-dependent changes of GnRH gene expression in rat ovary = 랫드의 연령에 따른 GnRH 유전자의 난소내 발현 변화

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Title
Age-dependent changes of GnRH gene expression in rat ovary = 랫드의 연령에 따른 GnRH 유전자의 난소내 발현 변화
Author(s)
Yong Joon Kim
Bibliographic Citation
Korean Journal of Laboratory Animal Science, vol. 10, no. 1, pp. 9-15
Publication Year
1994
Abstract
In SD rat, a change of ovarin GnRH mRNA level with age was investigated. E₂ and P concentrations in serum and ovary were determined by RIA. Slot-blot hybridization technique was used to scan GnRH mRNA level in rat ovary using synthetic GnRH oligomer probe labelled with ^(32)P by 5´-end labelling method. No significant change with ovarian aging was observed in P concentration, but a significant decreased E₂ level was found in 18 month-aged rat. And in comparision with 2 month-aged, ovarian GnRH mRNA level in 18 month-aged rat was markedly increased at 2.86 times. In conclusion, GnRH seems to related not only to control of ovarian activities but to aging of female reproductive organs including ovary.
ISSN
1225-813X
Publisher
South Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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