Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B

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Title
Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B
Author(s)
K Togashi; H R Ko; Jong Seog Ahn; H Osada
Bibliographic Citation
Bioscience Biotechnology and Biochemistry, vol. 65, no. 3, pp. 651-653
Publication Year
2001
Abstract
We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.
Keyword
screeningtelomeraseCRM646-Athielavin Breverse transcriptase
ISSN
0916-8451
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1271/bbb.65.651
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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