Binding and regulation of HIF-1α by a subunit of the proteasome complex, PSMA7

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dc.contributor.authorSa Yeon Cho-
dc.contributor.authorYoun Jeong Choi-
dc.contributor.authorJeong Min Kim-
dc.contributor.authorSeong Tae Jeong-
dc.contributor.authorJae Hoon Kim-
dc.contributor.authorSeung Ho Kim-
dc.contributor.authorSeong Eon Ryu-
dc.date.accessioned2017-04-19T08:58:16Z-
dc.date.available2017-04-19T08:58:16Z-
dc.date.issued2001-
dc.identifier.issn0014-5793-
dc.identifier.uri10.1016/S0014-5793(01)02499-1ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5536-
dc.description.abstractThe hypoxia-inducible factor-1α (HIF-1α) is an important transcription factor for cellular responses to oxygen tension. It is rapidly degraded under normoxic conditions by the ubiquitin-dependent proteasome pathway. Here we report a critical role of the 20S proteasome subunit PSMA7 in HIF-1α regulation. PSMA7 was found to interact specifically with two subdomains of HIF-1α. PSMA7 inhibited the transactivation function of HIF-1α under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1α activity is associated with the proteasome pathway.-
dc.publisherWiley-
dc.titleBinding and regulation of HIF-1α by a subunit of the proteasome complex, PSMA7-
dc.title.alternativeBinding and regulation of HIF-1α by a subunit of the proteasome complex, PSMA7-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number1-
dc.citation.endPage66-
dc.citation.startPage62-
dc.citation.volume498-
dc.contributor.affiliatedAuthorSa Yeon Cho-
dc.contributor.affiliatedAuthorYoun Jeong Choi-
dc.contributor.affiliatedAuthorJeong Min Kim-
dc.contributor.affiliatedAuthorSeong Tae Jeong-
dc.contributor.affiliatedAuthorJae Hoon Kim-
dc.contributor.affiliatedAuthorSeung Ho Kim-
dc.contributor.affiliatedAuthorSeong Eon Ryu-
dc.contributor.alternativeName조사연-
dc.contributor.alternativeName최윤정-
dc.contributor.alternativeName김정민-
dc.contributor.alternativeName정성태-
dc.contributor.alternativeName김재훈-
dc.contributor.alternativeName김승호-
dc.contributor.alternativeName류성언-
dc.identifier.bibliographicCitationFEBS Letters, vol. 498, no. 1, pp. 62-66-
dc.identifier.doi10.1016/S0014-5793(01)02499-1-
dc.subject.keywordhypoxia-
dc.subject.keywordhypoxia-inducible factor-1α-
dc.subject.keywordproteasome-
dc.subject.keywordPSMA7-
dc.subject.localhypoxia-
dc.subject.localHypoxia-
dc.subject.localhypoxia-inducible factor 1α-
dc.subject.localHypoxia-inducible factor-1α-
dc.subject.localhypoxia inducible factor-1α (HIF-1α)-
dc.subject.localhypoxia-inducible factor-1α-
dc.subject.localHypoxia inducible factor-1α-
dc.subject.localHypoxic inducible factor-1a-
dc.subject.localHypoxia-inducible factor 1 alpha-
dc.subject.localproteasome-
dc.subject.localProteasome-
dc.subject.localPSMA7-
dc.description.journalClassY-
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