Binding and regulation of HIF-1α by a subunit of the proteasome complex, PSMA7

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Title
Binding and regulation of HIF-1α by a subunit of the proteasome complex, PSMA7
Author(s)
Sa Yeon Cho; Youn Jeong Choi; Jeong Min Kim; Seong Tae Jeong; Jae Hoon Kim; Seung Ho Kim; Seong Eon Ryu
Bibliographic Citation
FEBS Letters, vol. 498, no. 1, pp. 62-66
Publication Year
2001
Abstract
The hypoxia-inducible factor-1α (HIF-1α) is an important transcription factor for cellular responses to oxygen tension. It is rapidly degraded under normoxic conditions by the ubiquitin-dependent proteasome pathway. Here we report a critical role of the 20S proteasome subunit PSMA7 in HIF-1α regulation. PSMA7 was found to interact specifically with two subdomains of HIF-1α. PSMA7 inhibited the transactivation function of HIF-1α under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1α activity is associated with the proteasome pathway.
Keyword
hypoxiahypoxia-inducible factor-1αproteasomePSMA7
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/S0014-5793(01)02499-1
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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