Enhanced IL-18 expression in common skin tumors

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Enhanced IL-18 expression in common skin tumors
Hyun Jeong Park; Dae Yoo Byun; Tae S Kim; Young I Kim; Jae S Kang; Eun S Hahm; Seong H Kim; Wang J Lee; Hyun Keun Song; Do Young Yoon; Chang J Kang; Chnag Nam Lee; Dong Houh; Hyung Ok Kim; Baik Kee Cho; Young Sill Kim; Yool H Yang; Kyung H Min; Dae H Cho
Bibliographic Citation
Immunology Letters, vol. 79, no. 3, pp. 215-219
Publication Year
Interleukin-18 (IL-18) has been found to have multiple effects upon various cells involved in inflammatory response. Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma. In this study, we investigated the pattern of IL-18 expression in the human system. IL-18 production was tested by enzyme linked immunosorbent assay (ELISA) assay in various tumor cell lines, including Raji (Burkett's lymphoma), IM-9 (B lymphoblast), Jurkat (acute T cell leukemia), SK-MES-1 (squamous cell carcinoma (SCC) cell line), SK-MEL-2, G-361, DM-4, and DX-3 (melanoma cell lines). ELISA tests showed that IL-18 was highly expressed in malignant skin tumors such as SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 production may be associated with the malignancy of skin tumors. Here, we report that enhanced IL-18 expression is positively correlated with malignant skin tumors such as SCC and melanoma, suggesting the importance role of IL-18 in malignancy of skin tumors. Taken together, expression of IL-18 by tumor cells in human skin tissue may provide an important clue to understand the pathogenesis of malignant skin tumors.
IL-18Skin tumorsSquamous cell carcinoma
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