5,6-Diphenylpyridazine derivatives as acyl-CoA : cholesterol acyltransferase inhibitors

Cited 24 time in scopus
Metadata Downloads
Title
5,6-Diphenylpyridazine derivatives as acyl-CoA : cholesterol acyltransferase inhibitors
Author(s)
Maria Palola Giovannoni; Vittorio Dal Piaz; Byoung-Mog Kwon; Mi Kyung Kim; Young Kook Kim; Lucio Toma; Daniela Barlocco; Franco Bernini; Monica Canavesi
Bibliographic Citation
Journal of Medicinal Chemistry, vol. 44, no. 24, pp. 4292-4295
Publication Year
2001
Abstract
Alkyl-5, 6-diphenylpyridazine derivatives combining several main features of ACAT inhibitors, such as a long alkyl side chain linked to a heterocycle and the o-diphenyl system, were synthesized and tested. Moreover, modeling studies on representative terms were performed. Some compounds displayed ACAT inhibition in the micromolar range, both on the enzyme isolated from rat liver microsomes and in cell-free homogenate of murine macrophages.
ISSN
0022-2623
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/jm010807h
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.