Open Access@KRIBBDivision of A.I. & Biomedical ResearchGenomic Medicine Research Center1. Journal Articles
Pleckstrin homology domain interacts with Rkp1/Cpc2, a RACK1 homolog, to modulate Pck2-mediated signaling process in Schizosaccharomyces pombe
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- Title
- Pleckstrin homology domain interacts with Rkp1/Cpc2, a RACK1 homolog, to modulate Pck2-mediated signaling process in Schizosaccharomyces pombe
- Author(s)
- Mi Sun Won; Young Joo Jang; Kyung Sook Chung; Dong Uk Kim; Kwang Lae Hoe; Mi Young Han; Hyung Bae Kim; Sang Hee Lee; Hyun Wha Oh; Hyang Sook Yoo
- Bibliographic Citation
- Biochemical and Biophysical Research Communications, vol. 289, no. 5, pp. 987-992
- Publication Year
- 2001
- Abstract
- Rkp1/Cpc2, a fission yeast RACK1 homolog, interacts with Pck2, a PKC homolog, and is involved in the regulation of pck2-mediated signaling process. The N-terminal region of split pleckstrin homology domain (nPH) in human PLC-γ1 bound to Rkp1/Cpc2 concomitantly with Pck2. nPH inhibited kinase activity of GST-Pck2 purified from Schizosaccharomyces pombe in vitro. The lethality induced by pck2+ overexpression was suppressed by coexpression of either rkp1+ or nPH domain. This result suggests that Rkp1/Cpc2 interacts with PH domain-containing protein and regulates the Pck2-mediated signaling process in S. pombe.
- ISSN
- 0006-291X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1006/bbrc.2001.6094
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Genomic Medicine Research Center > 1. Journal Articles
Center for Gene & Cell Theraphy > 1. Journal Articles
Division of A.I. & Biomedical Research > Digital Biotech Innovation Center > 1. Journal Articles
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