Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER Kinase homolog

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Title
Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER Kinase homolog
Author(s)
Kun Hoe Kim; Young Mi Cho; Won Hwa Kang; Ji Hoon Kim; Kwan Ho Byun; Yoon Dong Park; Kyung Sook Bae; Hee Moon Park
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 289, no. 5, pp. 1237-1242
Publication Year
2001
Abstract
We have isolated a full-length cDNA clone that encodes for a Schizosaccharomyces pombe homolog of the dual-specificity protein kinase of the LAMMER family, lkh1 (lammer kinase homolog). The proposed Lkh1 protein contains 575 amino acids. The lkh1+ null mutant is viable, but exhibits flocculation upon reaching stationary phase in liquid media and filamentous adhesion growth on solid media. Analysis of the flocculation activity of the lkh1+ null mutant indicates that asexual aggregation of S. pombe cells into floccules is divalent cation-dependent and galactose-specific. We also demonstrate that the Saccharomyces cerevisiae LAMMER kinase homolog, Kns1, can substitute for the Lkh1 function in S. pombe.
Keyword
Filamentous adhesionFlocculationKns1LAMMER kinaseLkh1S. cerevisiaeS. pombe
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1006/bbrc.2001.6128
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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