Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER Kinase homolog
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- Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER Kinase homolog
- Kun Hoe Kim; Young Mi Cho; Won Hwa Kang; Ji Hoon Kim; Kwan Ho Byun; Yoon Dong Park; Kyung Sook Bae; Hee Moon Park
- Bibliographic Citation
- Biochemical and Biophysical Research Communications, vol. 289, no. 5, pp. 1237-1242
- Publication Year
- We have isolated a full-length cDNA clone that encodes for a Schizosaccharomyces pombe homolog of the dual-specificity protein kinase of the LAMMER family, lkh1 (lammer kinase homolog). The proposed Lkh1 protein contains 575 amino acids. The lkh1+ null mutant is viable, but exhibits flocculation upon reaching stationary phase in liquid media and filamentous adhesion growth on solid media. Analysis of the flocculation activity of the lkh1+ null mutant indicates that asexual aggregation of S. pombe cells into floccules is divalent cation-dependent and galactose-specific. We also demonstrate that the Saccharomyces cerevisiae LAMMER kinase homolog, Kns1, can substitute for the Lkh1 function in S. pombe.
- Filamentous adhesion; Flocculation; Kns1; LAMMER kinase; Lkh1; S. cerevisiae; S. pombe
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