Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER Kinase homolog
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- Title
- Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER Kinase homolog
- Author(s)
- Kun Hoe Kim; Young Mi Cho; Won Hwa Kang; Ji Hoon Kim; Kwan Ho Byun; Yoon Dong Park; Kyung Sook Bae; Hee Moon Park
- Bibliographic Citation
- Biochemical and Biophysical Research Communications, vol. 289, no. 5, pp. 1237-1242
- Publication Year
- 2001
- Abstract
- We have isolated a full-length cDNA clone that encodes for a Schizosaccharomyces pombe homolog of the dual-specificity protein kinase of the LAMMER family, lkh1 (lammer kinase homolog). The proposed Lkh1 protein contains 575 amino acids. The lkh1+ null mutant is viable, but exhibits flocculation upon reaching stationary phase in liquid media and filamentous adhesion growth on solid media. Analysis of the flocculation activity of the lkh1+ null mutant indicates that asexual aggregation of S. pombe cells into floccules is divalent cation-dependent and galactose-specific. We also demonstrate that the Saccharomyces cerevisiae LAMMER kinase homolog, Kns1, can substitute for the Lkh1 function in S. pombe.
- Keyword
- Filamentous adhesionFlocculationKns1LAMMER kinaseLkh1S. cerevisiaeS. pombe
- ISSN
- 0006-291X
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1006/bbrc.2001.6128
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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