Citrinin hydrate inhibits serotonin N-acetyltransferase catalyzing the conversion of serotonin to N-acetylserotonin

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Title
Citrinin hydrate inhibits serotonin N-acetyltransferase catalyzing the conversion of serotonin to N-acetylserotonin
Author(s)
In Kyoung Lee; Bong Sik Yun; Kyong Tai Kim; Bo Hwa Choi; Tae Ju Park; Young Ho Kim; Ick Dong Yoo
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 11, no. 6, pp. 1099-1101
Publication Year
2001
Abstract
In an attempt to search for serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) inhibitors from microbial metabolites, we found the culture broth of Penicillium sp. 80722 which showed a strong inhibitory activity against AA-NAT. The active principle has been identified as citrinin hydrate through bioassay-guided fractionation of cultural broth, and structure elucidation derived by spectroscopic analyses. Citrinin hydrate inhibits AA-NAT with an IC50 value of 173 μM in a dose-dependent manner. Although citrinin hydrate was previously isolated as human rhinovirus 3C-protease inhibitor, this was recognized as the first AA-NAT inhibitor isolated from natural sources.
Keyword
citrinin hydratepenicillium sp.serotonin n-acetyltransferase (AA-NAT) inhibitor
ISSN
1017-7825
Publisher
South Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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