A cytotoxic secocycloartenoid from Abies koreana

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Title
A cytotoxic secocycloartenoid from Abies koreana
Author(s)
Hyun Jung Kim; Quoc Khanh Le; Mi Hyun Lee; Tae Sung Kim; Hyeong Kyu Lee; Young Ho Kim; Ki Hwan Bae; Ik Soo Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 24, no. 6, pp. 527-531
Publication Year
2001
Abstract
Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9β- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with β- sitosterol (2), maltol (3), β-sitosterol-O-β-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.
Keyword
Pinaceae24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid3- Oxo-9β-lanosta-7,22z,24-trien-26,23-olideAbies koreanaCytotoxicity
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02975159
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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