Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent

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Title
Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent
Author(s)
Jong Won Choi; Keun Huh; Suk Hwan Kim; Kyung Tae Lee; Hyeong Kyu Lee; Hee Juhn Park
Bibliographic Citation
Journal of Ethnopharmacology, vol. 79, no. 1, pp. 113-118
Publication Year
2002
Abstract
The stem bark of Kalopanax pictus is an anti-rheumatoidal arthritis drug in Oriental medicine. In the rheumatoidal rat, induced by Freund's complete adjuvant (FCA) reagent, we investigated the effects of hederagenin monodesmosides of K. pictus on oxidative stress and hepatic drug-metabolizing enzymes. Kalopanaxsaponin-A (KPS-A) significantly decreased malondialdehyde formation and the activities of xanthine oxidase and aldehyde oxidase of hepatic non-microsomal systems in FCA reagent-treated rats. In addition, increased activity levels of superoxide dismutase, catalase and glutathione peroxidase were also observed. The effects of KPS-A were more potent than the effects of KPS-I. These results suggested that KPS-A, extracted from K. pictus, could reduce rheumatoidal syndromes through antioxidative mechanisms.
Keyword
Freund's adjuvant reagentKalopanax pictusKalopanaxsaponin AMicrosomalOxidative stressRheumatoidal arthritis
ISSN
0378-8741
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0378-8741(01)00382-8
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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