Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells

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Title
Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells
Author(s)
Bang Yeon Hwang; Jeong Hyung Lee; Tae Hyeon Koo; Hang Sub Kim; Young Soo Hong; Jai Seup Ro; Kyong Soon Lee; Jung Joon Lee
Bibliographic Citation
Planta Medica, vol. 68, no. 2, pp. 101-105
Publication Year
2002
Abstract
Furanoligularenone (1), a known eremophilane, was identified from Ligularia fischeri (Compositae) together with 3-oxo-8α-hydroxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (2) and 3-oxo-8α-methoxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (3), by its potent inhibition of LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Compound 1 also suppressed the expression of iNOS and COX-2 mRNA and protein in a dose-dependent manner. Taken together, compound 1 inhibits the production of NO and PGE2 at the transcription of iNOS and COX-2 genes, and would be responsible for the anti-inflammatory activities of the Ligularia fischeri.
Keyword
CompositaeCyclooxygenase-2FuranoligularenoneInducible nitric oxide synthaseLigularia fischeriNF-κBNitric oxideProstaglandin E2
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2002-20250
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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