Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay

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Title
Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay
Author(s)
Choong Hwan Lee; Hyun A Kim; Yung Hee Kho
Bibliographic Citation
Journal of Natural Products, vol. 65, no. 3, pp. 414-416
Publication Year
2002
Abstract
Investigation of the whole plant of Agastache rugosa resulted in the isolation of two new lignan compounds. Their structures were elucidated as (8S, 7′R, 8′S)-4-hydroxybenzoic acid 4-(4-hydroxy-3-methoxybenzyl)2-(4-hydroxy-3-methoxyphenyl) tetrahydrofuran-3-ylmethyl ester (agastinol, 1) and (7′R, 8′S)-4-hydroxybenzoic acid 4-(hydroxy-3-methoxybenzylidene)-2-(4-hydroxy-3-methoxyphenyl)- tetrahydrofuran-3ylmethyl ester (agastenol, 2). Agastinol and agastenol inhibited etoposide-induced apoptosis in U937 cells with IC50 values of 15.2 and 11.4μg/mL, respectively.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np010425e
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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