Novel α-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416 III : physico-chemical properties and structure elucidation

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Title
Novel α-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416 III : physico-chemical properties and structure elucidation
Author(s)
Hung Bae Chang; Sun Ho Kim; Young In Kwon; Dong Ho Choung; Won Kyu Choi; Tae Won Kang; Sung Sook Lee; Jong Gwan Kim; Hyoung Sik Chun; Soon Kil Ahn; Chung Il Hong; Kyou Hoon Han
Bibliographic Citation
Journal of Antibiotics, vol. 55, no. 5, pp. 467-471
Publication Year
2002
Abstract
We have isolated two novel α-glucosidase inhibitors, O-[4-deoxy-4-(2,3-epoxy-3-hydroxymethyl-4,5,6-trihydroxycyclohexane- 1-y1-amino)-α-D-glucopyranosyl]- (1→4)-O-α-D-glucopyranosyl- (1→4)-α-D-glucopyranose (named CKD-711) and its hexameric analog CKD-711a, from the fermentation broth of Streptomyces sp. CK-4416. HRFAB-MS and NMR analyses reveal that molecular formulae of CKD-711 and CKD-711a are C25H43NO20 and C37H63NO30, respectively with the latter containing two more glucose moieties than the former. Detailed chemical structures of both compounds have been characterized by high-resolution two-dimensional NMR methods.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.55.467
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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