The VHR Dual-Specificity Protein Tyrosine Phosphatase (DS-PTPase) inhibitor isolated from Gastrodia elata = 천마(Gastrodia elata)로부터 분리한 VHR DS-PTPase 저해 물질

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Title
The VHR Dual-Specificity Protein Tyrosine Phosphatase (DS-PTPase) inhibitor isolated from Gastrodia elata = 천마(Gastrodia elata)로부터 분리한 VHR DS-PTPase 저해 물질
Author(s)
Myung Sun Lee; Won Keun Oh; Eun Young Bae; Soon Cheol Ahn; Cheon Bae Sohn; Hiroyuki Osada; Jong Seog Ahn
Bibliographic Citation
Korean Journal of Food Science & Technology, vol. 34, no. 3, pp. 505-509
Publication Year
2002
Abstract
In the course of screening program for VHR DS-PTPase (dual-specificity protein tyrosine phosphatase) from natural sources, Gastrodia elata was selected. One compound showing potent inhibitory activity was isolated by the solvent extraction and column chromatography including silica gel, ODS RP-18, Sephades LH-20, and HPLC. This compound was identified as baicalein by several NMR techniques such as , , and DEPT. Baicalein showed selective inhibitory activity against VHR DS-PTPase with , and showed cytotoxicity against several human cancer cell lines with an of range, including, melanoma (LOX-IMVI), lung cancer (NCI H23 and A549), colon cancer (HCT 116 and SW 620), prostate cancer (PC-3), and leukemia (MOLT 4F).
Keyword
gastrodia elataVHR DS-PTPasebaicaleincytotoxicity
ISSN
0367-6293
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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