Screening of Korean medicinal and food plants with antitumoral activity = 국내 약용 및 식용식물중 항종양활성 식물탐색

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Title
Screening of Korean medicinal and food plants with antitumoral activity = 국내 약용 및 식용식물중 항종양활성 식물탐색
Author(s)
Il Min Chung; Kwang Ho Kim; Joung Kuk Ahn; Jong Seog Ahn; Soon Cheol Ahn
Bibliographic Citation
Korean Journal of Medicinal Crop Science, vol. 7, no. 1, pp. 37-44
Publication Year
1999
Abstract
This study was conducted to screen antitumoral activity by in vitro bioassay method using 60 Korean medicinal and food plants extracted by 80% EtOH. Antitumor activity test was applied by the PKC(protein kinase C) and antibleb formation, PLC(Phospholipase C), and colorimetric tetrazolium assay(MTT assay) methods. Chenopodium album and black Glycine max showed high antitumoral activity by 73.5% and 81.0%, respectively, against PKC by bleb-forming assay and PKC enzyme assay on human chronic leukemia K562 cell. Black Glycine max also showed 91.2% antitumoral activity in the PLC method and the lowest IC_(50) value (4.7㎍/㎖) by MTT method against P-338 cell line. In the effect of the concentration treatment on antitumoral test, the more concentration indicated the more activity value.
Keyword
native plantsantitumoral activityPKCMTT assayPLC
ISSN
I000-0107
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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