Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis

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Title
Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis
Author(s)
H J Jung; Byung Sun Min; J Y Park; Y H Kim; Hyeong Kyu Lee; K H Bae
Bibliographic Citation
Journal of Natural Products, vol. 65, no. 6, pp. 897-901
Publication Year
2002
Abstract
Six new polyacetylenes, gymnasterkoreaynes A-F (1-6), were isolated from the roots of Gymnaster koraiensis, together with 2,9,16-heptadecatrien-4,6-diyn-8-ol (7) and 1,9,16-heptadecatriene-4,6-diyn-3,8-diol (8), by bioassay-guided fractionation using the L1210 tumor cell line as a model for cytotoxicity. The structures of compounds 1-6 were established spectroscopically, which included 2D NMR experiments. Gymnasterkoreaynes A-F (1-6) are linear diacetylenes and are structurally related to falcarinol, panaxynol, panaxydiol, and panaxytriol. of the compounds isolated, gymnasterkoreaynes B (2), C (3), F (6), and 1,9,16-heptadecatrien-4,6-diyn-3,8-diol (8) exhibited significant cytotoxicity against L1210 tumor cells with ED50 values of 0.12-3.3 μg/mL.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np0104018
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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