Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza
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- Title
- Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza
- Author(s)
- Jeong Suk Ko; S Y Ryu; Y S Kim; Mi Yeon Chung; J S Kang; Mun Chual, Rho; Hyun Sun Lee; Young Kook Kim
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 25, no. 4, pp. 446-448
- Publication Year
- 2002
- Abstract
- The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 μg/ml and 11.1 μg/ml. However, tanshinone IIA (2) and tanshinone I (4) showed very weak inhibition (IC50 value: > 250 μg/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Full Text Link
- http://dx.doi.org/10.1007/bf02976599
- Type
- Article
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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